The 2025/26 Europa League continues later this evening with Matchday 4.
The stakes are high: several teams are already fighting for direct qualification to the Round of 16, while others are battling to secure at least a play-off spot.
Among the sides to watch, Olympique Lyonnais remain unbeaten with three wins in as many games, and they face Real Betis, still looking to find their rhythm.
Here are a few online betting predictions for some of the most exciting fixtures, along with the best football odds to help guide your bets. With the Cash Card, you can also play online through our brand-new app by making deposits at any retail point.
Europa League 2025/26: Our Matchday 4 Betting Tips
*All odds are subject to change
Nice to beat Freiburg @ 2.65
Nice’s European campaign has been disastrous so far, but against Freiburg, a reaction from the Aiglons is expected. Freiburg, meanwhile, boast an impressive record with two wins and a draw, currently sitting sixth in their domestic league.
However, Julian Schuster’s men have shown signs of vulnerability away from home, particularly in the Bundesliga. In front of their fans, Nice — still without a point — must step up and deliver a convincing performance.
Real Betis to beat Lyon @ 1.72
Real Betis host Lyon with the goal of reigniting their European run. The Andalusian side haven’t yet found full consistency but have the squad depth to make a difference at home. Lyon, on the other hand, have made a perfect start with three wins and no goals conceded.
However, coach Paulo Fonseca is expected to rotate his squad heavily, and with Betis eager to impress their supporters, the 1.72 odds on a home win looks like a smart pick.
Braga vs Racing Genk: Draw or Genk @ 2.53
Sporting Braga welcome KRC Genk in a matchup where the Portuguese side are slight home favourites. That said, Genk, who recently held Real Betis to a 0–0 draw, have plenty of room to improve and could at least secure a draw here.
Braga’s strong start to the competition won’t make things easy, but the Belgian side’s ability to play on the counter could pay off against an attacking opponent.
Glasgow Rangers vs AS Roma: Matías Soulé to score anytime @ 3.32
Rangers, struggling so far in the competition, host AS Roma, who are looking to bounce back after some mixed results. Argentinian winger Matías Soulé has been one of the revelations of the 2025/26 season, confirming his potential as one of Serie A’s brightest young talents.
Domestically, he’s already contributed goals and assists, and although he hasn’t yet scored in Europe, his attacking activity — 11 shots so far — suggests he could finally find the net against the Scottish side.
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