The Jupiler Pro League continues this weekend with Matchday 6 of the 2025-26 season.
On the program, a top-of-the-table clash between reigning champions Union Saint-Gilloise and title contenders Anderlecht, who are gaining some serious momentum.
We’ll also be keeping an eye on Club Brugge’s trip to Gent, as well as a crucial bottom-of-the-table battle between Charleroi and Dender, with survival already becoming a big talking point.
Here are our betting predictions for some of these Matchday 6 fixtures in the Jupiler Pro League, along with the latest football bet odds available on our online betting site. Don’t forget you can also use our Cash Out option to secure your winnings before the final whistle is blown by the referee.
*All odds are subject to change
Union Saint-Gilloise vs Anderlecht: Over 3.5 goals @ 2.98
Union Saint-Gilloise and Anderlecht have displayed similar attacking stats in recent weeks, with both sides scoring six goals across their last three league games (an average of two per match). USG, combining a solid defense with clinical finishing, face a confident Anderlecht side, who are riding the wave of a strong start to the season and boast an in-form attacker in Thorgan Hazard. This Brussels derby has all the ingredients for a goal-fest, and could easily surpass the 3.5-goal mark.
Draw between Gent and Club Brugge @ 4.30
Gent remain tough to beat at home, while Brugge often impose themselves early on in away matches. This looks like a tightly contested battle where neither side is likely to run away with it. Club Brugge will be desperate to avoid falling too far behind in the standings, while Gent might struggle for rhythm after their Matchday 5 fixture was postponed. Everything points towards a balanced affair and a share of the spoils.
KV Mechelen to beat La Louvière @ 1.78
Few expected Mechelen to be mixing it with the upper half of the table. Calm and well-organized under Frédéric Vanderbiest, they come into this game after a defeat against Antwerp but still sit 6th in the table, just three points off second place. La Louvière, despite their efforts, are struggling to adapt to top-flight football with just one win from their opening five games. Mechelen look well positioned to take advantage and claim three important points.
Charleroi to beat Dender @ 1.82
Two winless teams clash in what could already be a turning point in their seasons. Charleroi, with more experience and greater collective solidity, hold a slight edge over Dender. In a must-win relegation battle, the Zebras appear better equipped to finally pick up their first victory and give their fans something to cheer about.
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